JellyBlue Official Website › Side Effects
Side effects and safetyJellyBlue Side Effects: Safety Notes For Each Active, And The Label Caution
The JellyBlue label caution says anyone pregnant or nursing, anyone under 18 and anyone with a known medical condition should consult a physician before use.
The actives with the most safety literature are ashwagandha (drowsiness, stomach upset, rare liver injury, several medicine interactions) and horny goat weed, whose flavonoids act on the PDE5 enzyme in the laboratory. Take one gummy a day and no more.
The JellyBlue label caution, word for word
One caution block, quoted in full, and what each part of it covers.
“Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of reach of children. Do not use if safety seal is damaged or missing.”
Do not exceed the dose
One gummy a day is the whole serving. Two gummies is not a faster route; it is simply more than the label directs.
Pregnant or nursing
Named first. NCCIH also says ashwagandha should be avoided in pregnancy and not used while breastfeeding.
Under 18
The product is for adults 18 and over. Keep the bottle out of reach of children, as the label says.
A known medical condition
Any diagnosed condition, and by extension any regular medicine, is a reason to ask a doctor before the first gummy.
JellyBlue safety notes, active by active
What the cited research and the federal health pages say about each row on the panel.
| Active | Panel | What the safety literature says | Source |
|---|---|---|---|
| L-Arginine HCl | 50 mg | An amino acid in ordinary protein foods. Its research concerns nitric oxide and blood vessels, in trials that gave 1,500 to 5,000 mg a day. | Rhim 2019 |
| Tongkat Ali extract | 200 mg | The twelve-week trial at 100 and 200 mg reported no safety-related, clinically relevant changes. A 2004 survey found mercury in 36 of 100 preparations sold in Malaysia. | Chinnappan 2021; Ang 2004 |
| Maca root extract | 100 mg | Reviewed among herbal sexual enhancers; most appeared safe at usual doses, with problems mainly from overdosing or unstandardised products. | Brunetti 2020 |
| Ashwagandha extract | 100 mg | Drowsiness, stomach upset, diarrhoea and vomiting in some people; rare cases of liver injury; several medicine interactions; avoid in pregnancy and breastfeeding. | NCCIH; LiverTox |
| Horny goat weed extract | 100 mg | Three of its flavonoids inhibit PDE5A in the laboratory, the enzyme some prescription medicines act on. | Li 2022 |
| Beet root extract | 50 mg | A nitrate source. Beetroot juice at 200 to 800 mg of nitrate lowered systolic pressure in people with high blood pressure. | Grönroos 2024 |
| Grape seed extract | 50 mg | Nineteen trials found diastolic pressure 2.20 mmHg lower on average, varying with dose and duration. | Foshati 2022 |
Findings from each ingredient's own research, at the doses those studies used. None tested this gummy.
Medicines to raise before taking JellyBlue
The label's caution names medical conditions in general. These are the specific medicines the research points at.
Blood pressure medicines
NCCIH lists them among ashwagandha's possible interactions, and three more rows are researched for blood pressure and blood vessels: beet root, grape seed and arginine.
PDE5 medicines and nitrates
Horny goat weed's flavonoids act on PDE5 in the laboratory; arginine and beet root feed the nitric-oxide pathway. Ask the prescriber before combining them.
Diabetes medicines
Named by NCCIH as a possible ashwagandha interaction. A doctor can say whether any monitoring should change.
Thyroid hormone
NCCIH lists thyroid hormone medicines as an interaction and does not recommend ashwagandha for people with thyroid disorders.
Immune, sedative and seizure medicines
Immunosuppressants, sedatives and anticonvulsants are all on NCCIH's interaction list for ashwagandha.
Surgery and prostate cancer
NCCIH does not recommend ashwagandha before surgery, or for people with autoimmune disorders, and advises people with hormone-sensitive prostate cancer to avoid it.
How long JellyBlue packs run against the safety data
Ashwagandha is the one active with a stated safe span, and the packs run on either side of it.
NCCIH says ashwagandha may be safe for up to about three months and that there is not enough information on longer use. Two and three bottles sit inside that span. A six-bottle order runs twice as long, so a buyer taking it through should mention it to a doctor at the three-month mark.
Effects a JellyBlue buyer may notice
The effects the ingredient research and NCCIH list, from the mild ones to the ones that need a doctor.
A settling stomach
Stomach upset, diarrhoea and vomiting are listed for ashwagandha in some people. Taking the gummy with its 8 oz glass of water, as the label says, is the first step; if it persists, stop.
Drowsiness
Also listed for ashwagandha. If it appears, notice when, and do not drive until you know how the gummy affects you.
Signs to stop at once
Yellowing skin or eyes, dark urine, unusual tiredness or itching can signal liver trouble, the rare problem linked to ashwagandha. Stop and see a doctor.
Sugar
1.5 g of total sugars a gummy, 6 calories. Small, but worth counting for anyone who tracks sugar closely.
Category risks JellyBlue buyers should know
Two documented problems in this category, and what can and cannot be checked about this bottle.
Products sold for male vitality carry the heaviest adulteration record in the supplement market. A study of FDA warnings from 2007 through 2016 found 776 adulterated supplements, 353 of them marketed for sexual enhancement; sildenafil was the hidden drug in 166 of those. A 2021 review lists acute liver injury, kidney failure, pulmonary embolism and stroke among the adverse events reported from such products, and advises treating them as adulterated until shown otherwise.
Tongkat ali has a quality record of its own. A 2004 survey of 100 tongkat ali preparations sold in Malaysia found mercury at 0.52 to 5.30 ppm in 36 of them, above the Malaysian limit, and warned of batch-to-batch inconsistency.
Where JellyBlue stands
The JellyBlue label lists seven actives with an amount for each and names no drug. No independent laboratory assay of this product has been published, and the label does not name the tongkat ali extract or its source, so neither question can be settled from outside. Buying from an authorized retailer and keeping the lot number, JEL-26/GO-5083 in the current run, is what a buyer can do. MedlinePlus, the National Library of Medicine’s health site, keeps a plain-language guide to the questions worth asking about any herbal product.
If something feels wrong after a JellyBlue gummy
Four steps, in this order.
Stop taking it
Do not take the next gummy until you know what is happening.
Keep the bottle
The label and the lot on the base, JEL-26/GO-5083 in the current run, tell a doctor exactly what you took.
See a doctor
Take the bottle with you. For a severe reaction, call 911.
Report it
Adverse events can be reported to the FDA's MedWatch program. For a refund inside the 60 days, call +1 (302) 200-3480 with the order ID.
JellyBlue safety questions
Side effects, medicines, long use, children and double doses.
Does JellyBlue have side effects?
Can I take JellyBlue with blood pressure medicine?
Can I take JellyBlue with a prescription erection medicine or a nitrate?
Is JellyBlue safe to take for six months?
What if a child eats JellyBlue gummies?
Can JellyBlue cause an allergic reaction?
What if I take two JellyBlue gummies by mistake?
Sources for the JellyBlue safety page
The federal health pages and studies behind every safety note above. MedlinePlus keeps a plain-language guide to herbal medicines.
- Ashwagandha. National Center for Complementary and Integrative Health, National Institutes of Health. https://www.nccih.nih.gov/health/ashwagandha
- Ashwagandha. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda MD. https://www.ncbi.nlm.nih.gov/books/NBK548536/
- Chinnappan SM, George A, Pandey P, et al. Effect of Eurycoma longifolia standardised aqueous root extract-Physta on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study. Food Nutr Res. 2021;65:5647. PMID 34262417. https://pubmed.ncbi.nlm.nih.gov/34262417/
- Ang HH, Lee EL, Cheang HS. Determination of mercury by cold vapor atomic absorption spectrophotometer in Tongkat Ali preparations obtained in Malaysia. Int J Toxicol. 2004;23(1):65-71. PMID 15162849. https://pubmed.ncbi.nlm.nih.gov/15162849/
- Brunetti P, Lo Faro AF, Tini A, et al. Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects. Pharmaceuticals (Basel). 2020;13(10):309. PMID 33066617. https://pubmed.ncbi.nlm.nih.gov/33066617/
- Li J, Wu Y, Yu X, et al. Isolation, bioassay and 3D-QSAR analysis of 8-isopentenyl flavonoids from Epimedium sagittatum maxim. as PDE5A inhibitors. Chin Med. 2022;17(1):147. PMID 36587222. https://pubmed.ncbi.nlm.nih.gov/36587222/
- Rhim HC, Kim MS, Park YJ, et al. The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis. J Sex Med. 2019;16(2):223-234. PMID 30770070. https://pubmed.ncbi.nlm.nih.gov/30770070/
- Grönroos R, Eggertsen R, Bernhardsson S, Praetorius Björk M. Effects of beetroot juice on blood pressure in hypertension according to European Society of Hypertension Guidelines: A systematic review and meta-analysis. Nutr Metab Cardiovasc Dis. 2024;34(10):2240-2256. PMID 39069465. https://pubmed.ncbi.nlm.nih.gov/39069465/
- Foshati S, Nouripour F, Sadeghi E, Amani R. The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis. Pharmacol Res. 2022;175:105905. PMID 34798267. https://pubmed.ncbi.nlm.nih.gov/34798267/
- Tucker J, Fischer T, Upjohn L, et al. Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings. JAMA Netw Open. 2018;1(6):e183337. PMID 30646238. https://pubmed.ncbi.nlm.nih.gov/30646238/
- Yéléhé-Okouma M, Pape E, Humbertjean L, et al. Drug adulteration of sexual enhancement supplements: a worldwide insidious public health threat. Fundam Clin Pharmacol. 2021;35(5):792-807. PMID 33484004. https://pubmed.ncbi.nlm.nih.gov/33484004/
- Herbal Medicine. MedlinePlus, U.S. National Library of Medicine. https://medlineplus.gov/herbalmedicine.html
More on taking JellyBlue safely
Order JellyBlue with the label in view
Read the caution and the panel first. Every order has 60 days from purchase to ask for a refund.
Two, three or six bottles · free US shipping on three and six · 60 days from the day you pay
Order JellyBlue On The Official WebsiteOne gummy a day · 30 to a bottle · lot JEL-26/GO-5083
